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KMID : 0191120170320050744
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Journal of Korean Medical Science
2017 Volume.32 No. 5 p.744 ~ p.749
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Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea
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Kang Chang-Kyung
Song Kyoung-Ho
Choe Pyoeng-Gyun
Park Wan-Beom
Bang Ji-Hwan
Kim Eu-Suk
Park Sang-Won
Kim Hong-Bin
Kim Nam-Joong
Cho Sung-Il
Lee Jong-Koo
Oh Myoung-Don
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Abstract
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Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38?22.30; P = 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93?27.79; P = 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09?1.60; P = 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; P = 0.061). Early active quarantine might help reducing the size of an outbreak.
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KEYWORD
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MERS-CoV, Outbreak, Hospital Infection, Infection Transmission, Korea
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